OUR RESEARCH

GRANT HIGHLIGHTS:

Marmo-AD: Afonso Silva, Stacey Rizzo and their team propose to establish the marmoset as the first primate-specific model to reveal the earliest cellular and molecular events of AD processes and allow charting AD progression from its inception.

DNA damage-induced inflammation and its brain-specific consequences: Karl Herrup and his team will test each cell type in the brain for its role in contributing to the chronic inflammation found in Alzheimer’s and Parkinson’s.

Hot Flashes and Brain Aging in Women: Rebecca Thurston and her team are examining whether hot flashes, night sweats and sleep problems, the major symptoms of menopause, are associated with declines in cognitive and brain health over time in women. Find out more about their work here.

In the News

Scientific Publications of 2024:

Single-cell multiregion dissection of Alzheimer’s disease

Plasma p-tau231 and p-tau217 inform on tau tangles aggregation in cognitively impaired individuals

Multi-transcriptomics reveals brain cellular responses to peripheral infection in Alzheimer’s disease model mice

CenTauR: Toward a universal scale and masks for standardizing tau imaging studies

Astrocyte reactivity influences amyloid-β effects on tau pathology in preclinical Alzheimer’s disease

Preanalytical stability of plasma/serum brain-derived tau

Meta-analysis of age-related cognitive decline reveals a novel locus for the attention domain and implicates a COVID-19-related gene for global cognitive function

Meeting report of the annual workshop on Principles and Techniques for Improving Preclinical to Clinical Translation in Alzheimer’s Disease research

Plasma phospho-tau in Alzheimer’s disease: towards diagnostic and therapeutic trial applications

Blood-brain barrier integrity impacts the use of plasma amyloid-β as a proxy of brain amyloid-β pathology

Potential Utility of Plasma P-Tau and Neurofilament Light Chain as Surrogate Biomarkers for Preventive Clinical Trials

Plasma biomarkers identify older adults at risk of Alzheimer’s disease and related dementias in a real-world population-based cohort

Carotid intima media thickness and white matter hyperintensity volume among midlife women

Discriminative accuracy of the A/T/N scheme to identify cognitive impairment due to Alzheimer’s disease

Scientific Publications Highlight:

Single-cell multiregion dissection of Alzheimer’s disease

Plasma p-tau231 and p-tau217 inform on tau tangles aggregation in cognitively impaired individuals

Multi-transcriptomics reveals brain cellular responses to peripheral infection in Alzheimer’s disease model mice

CenTauR: Toward a universal scale and masks for standardizing tau imaging studies

Astrocyte reactivity influences amyloid-β effects on tau pathology in preclinical Alzheimer’s disease

Preanalytical stability of plasma/serum brain-derived tau

Meta-analysis of age-related cognitive decline reveals a novel locus for the attention domain and implicates a COVID-19-related gene for global cognitive function

Meeting report of the annual workshop on Principles and Techniques for Improving Preclinical to Clinical Translation in Alzheimer’s Disease research

Plasma phospho-tau in Alzheimer’s disease: towards diagnostic and therapeutic trial applications

Blood-brain barrier integrity impacts the use of plasma amyloid-β as a proxy of brain amyloid-β pathology

Potential Utility of Plasma P-Tau and Neurofilament Light Chain as Surrogate Biomarkers for Preventive Clinical Trials

Plasma biomarkers identify older adults at risk of Alzheimer’s disease and related dementias in a real-world population-based cohort

Carotid intima media thickness and white matter hyperintensity volume among midlife women

Discriminative accuracy of the A/T/N scheme to identify cognitive impairment due to Alzheimer’s disease